In that case, the lab may do a blood smear and directly examine the platelets under a microscope. Sometimes during the test, platelets stick together and the machine gives a false reading, interpreting it as fewer, larger platelets. A normal PDW indicates platelets that are mostly the same size, while a high PDW means that platelet size varies greatly, a clue that there is platelet activation and has been associated with vascular diseases and certain cancers. PDW reflects how uniform the platelets are in size. Larger platelets are usually younger platelets that have been released earlier than normal from the bone marrow, while smaller platelets may be older and have been in circulation for a few days. This marker can give you additional information about your platelets and the cause of a high or low platelet count. Platelets play an important role in the processes of coagulation, inflammation, and immune response. Platelet distribution width (PDW) reflects variability in platelet size, and is considered a marker of platelet function and activation. What is Platelet distribution width (PDW)?
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